Evolutionary Conservation of Bacterial Essential Metabolic Genes across All Bacterial Culture Media
نویسندگان
چکیده
منابع مشابه
Evolutionary Conservation of Bacterial Essential Metabolic Genes across All Bacterial Culture Media
One of the basic postulates of molecular evolution is that functionally important genes should evolve slower than genes of lesser significance. Essential genes, whose knockout leads to a lethal phenotype are considered of high functional importance, yet whether they are truly more conserved than nonessential genes has been the topic of much debate, fuelled by a host of contradictory findings. H...
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Essential genes constitute the core of genes which cannot be mutated too much nor lost along the adaptive evolutionary history of a species. Natural selection is expected to be stricter on essential genes and on conserved (highly shared) genes, than on genes that are either nonessential or peculiar to a single or a few species. In order to further assess this expectation, we study here how esse...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2015
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0123785